La publication est essentielle pour communiquer les progrès scientifiques que nous réalisons à mesure que nous traduisons la connaissance scientifique que nous avons des enzymes NOX en candidats médicaments viables et, au final, en médicaments innovants pour les patients.


Acute Changes in NADPH Oxidase 4 in Early Post-Traumatic Osteoarthritis

Wegner AM, Campos NR, Robbins MA, Haddad AF, Cunningham HC, Yik JHN, Christiansen BA, Haudenschild DR. J Orthop Res. 2019 Jul 15

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NADPH oxidase 4 mediates TGF-β1/Smad signaling pathway induced acute kidney injury in hypoxia

Cho S, Yu SL, Kang J, Jeong BY, Lee HY, Park CG, Yu YB, Jin DC, Hwang WM, Yun SR, Song HS, Park MH, Yoon SH. PLoS One. 2019 Jul 18;14(7)

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Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice

Nishio T, Hu R, Koyama Y, Liang S, Rosenthal SB, Yamamoto G, Karin D, Baglieri J, Ma HY, Xu J, Liu X, Dhar D, Iwaisako K, Taura K, Brenner DA, Kisseleva T. J Hepatol. 2019 Sep;71(3):573-585

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Nox2 and Nox4 Participate in ROS-Induced Neuronal Apoptosis and Brain Injury During Ischemia-Reperfusion in Rats

Wang J, Liu Y, Shen H, Li H, Wang Z, Chen G. Acta Neurochir Suppl. 2020;127:47-54

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Inhibition of host NOX1 blocks tumor growth and enhances checkpoint inhibitor-based immunotherapy

Stalin J, Garrido-Urbani S, Heitz F, Szyndralewiez C, Jemelin S, Coquoz O, Ruegg C, Imhof BA. Life Sci Alliance. 2019 Jun 27;2(4)

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Nox4 is a Target for Tuberin Deficiency Syndrome.

Shi Q, Viswanadhapalli S, Friedrichs WE, Velagapudi C, Szyndralewiez C, Bansal S, Bhat MA, Choudhury GG, Abboud HE. Sci Rep. 2018 Feb 28;8(1):3781

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Inhibition of Nox4-dependent ROS signaling attenuates prostate fibroblast activation and abrogates stromal-mediated pro-tumorigenic interactions.

Sampson N, Brunner E, Weber A, Puhr M, Schäfer G, Szyndralewiez C, Klocker H. Int J Cancer. 2018 Feb 14.

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Effect of NADPH oxidase 1 and 4 blockade in activated human retinal endothelial cells.

Appukuttan B, Ma Y, Stempel A, Ashander LM, Deliyanti D, Wilkinson-Berka JL, Smith JR. Clin Exp Ophthalmol. 2018 Jan 23.

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VEGFR (Vascular Endothelial Growth Factor Receptor) Inhibition Induces Cardiovascular Damage via Redox-Sensitive Processes.

Neves KB, Rios FJ, van der Mey L, Alves-Lopes R, Cameron AC, Volpe M, Montezano AC, Savoia C, Touyz RM. Hypertension. 2018 Apr;71(4):638-647

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TGF-β-mediated NADPH oxidase 4-dependent oxidative stress promotes colistin-induced acute kidney injury.

Jeong BY, Park SR, Cho S, Yu SL, Lee HY, Park CG, Kang J, Jung DY, Park MH, Hwang WM, Yun SR, Jung JY, Yoon SH. J Antimicrob Chemother. 2018 Jan 9.

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Oxidative stress caused by activation of NADPH oxidase 4 promotes contrast-induced acute kidney injury.

Jeong BY, Lee HY, Park CG, Kang J, Yu SL, Choi DR, Han SY, Park MH, Cho S, Lee SY, Hwang WM, Yun SR, Ryu HM, Oh EJ, Park SH, Kim YL, Yoon SH. PLoS One. 2018 Jan 12;13(1):e0191034.

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Danshenol A inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1) mediated by NOX4 in endothelial cells.

Zhao W, Feng H, Guo S, Han Y, Chen X. Sci Rep. 2017 Oct 11;7(1):12953.

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TRAF3IP2 mediates high glucose-induced endothelin-1 production as well as endothelin-1-induced inflammation in endothelial cells.

Padilla J, Carpenter AJ, Das NA, Kandikattu HK, López-Ongil S, Martinez-Lemus LA, Siebenlist U, DeMarco VG, Chandrasekar B. Am J Physiol Heart Circ Physiol. 2018 Jan 1;314(1):H52-H64.

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Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4.

Hanley CJ, Mellone M, Ford K, Thirdborough SM, Mellows T, Frampton SJ, Smith DM, Harden E, Szyndralewiez C, Bullock M, Noble F, Moutasim KA, King EV, Vijayanand P, Mirnezami AH, Underwood TJ, Ottensmeier CH, Thomas GJ. J Natl Cancer Inst. 2018 Jan 1;110(1).

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Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis.

Cao Z, Ye T, Sun Y, Ji G, Shido K, Chen Y, Luo L, Na F, Li X, Huang Z, Ko JL, Mittal V, Qiao L, Chen C, Martinez FJ, Rafii S, Ding BS. Sci Transl Med. 2017 Aug 30;9(405).

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Lysocardiolipin acyltransferase regulates TGF-β mediated lung fibroblast differentiation.

Huang LS, Jiang P, Feghali-Bostwick C, Reddy SP, Garcia JGN, Natarajan V. Free Radic Biol Med. 2017 Nov;112:162-173.

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Cyclic mechanical stretch-induced oxidative stress occurs via a NOX-dependent mechanism in type II alveolar epithelial cells.

Tanaka T, Saito Y, Matsuda K, Kamio K, Abe S, Kubota K, Azuma A, Gemma A. Respir Physiol Neurobiol. 2017 Aug;242:108-116.

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Involvement of Nox2 and Nox4 NADPH oxidases in early brain injury after subarachnoid hemorrhage.

Zhang L, Li Z, Feng D, Shen H, Tian X, Li H, Wang Z, Chen G. Free Radic Res. 2017 Mar;51(3):316-328.

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Signalling mechanisms mediating Zn2+-induced TRPM2 channel activation and cell death in microglial cells.

Mortadza SS, Sim JA, Stacey M, Jiang LH. Sci Rep. 2017 Mar 21;7:45032.

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Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease.

Gray SP, Jha JC, Kennedy K, van Bommel E, Chew P, Szyndralewiez C, Touyz RM, Schmidt HHHW, Cooper ME, Jandeleit-Dahm KAM. Diabetologia. 2017 May;60(5):927-937.

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NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis and Bioenergetics in Lung Fibroblasts via a Nuclear Factor Erythroid-Derived 2-like 2 (Nrf2)-Dependent Pathway.

Bernard K, Logsdon NJ, Miguel V, Benavides GA, Zhang J, Carter AB, Darley-Usmar VM, Thannickal VJ. J Biol Chem. 2017 Jan 3. pii: jbc.M116.752261

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CFTR impairment upregulates c-Src activity through IL-1β autocrine signaling.

Massip-Copiz MM, Clauzure M, Valdivieso ÁG, Santa-Coloma TA. Arch Biochem Biophys. 2017 Jan 11;616:1-12.

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The role of the Nox4-derived ROS-mediated RhoA/Rho kinase pathway in rat hypertension induced by chronic intermittent hypoxia.

Lu W, Kang J, Hu K, Tang S, Zhou X, Xu L, Li Y, Yu S. Sleep Breath. 2017 Jan 11

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Tert-butyl hydroperoxide (t-BHP) induced apoptosis and necroptosis in endothelial cells: Roles of NOX4 and mitochondrion.

Zhao W, Feng H, Sun W, Liu K, Lu JJ, Chen X. Redox Biol. 2017 Jan 5;11:524-534

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Critical role of X-box binding protein 1 in NADPH oxidase 4-triggered cardiac hypertrophy is mediated by receptor interacting protein kinase 1.

Chen L, Zhao M, Li J, Wang Y, Bao Q, Wu S, Deng X, Tang X, Wu W, Liu X. Cell Cycle. 2016 Dec 8:0

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NOX4 supports glycolysis and promotes glutamine metabolism in non-small cell lung cancer cells.

Zeng C, Wu Q, Wang J, Yao B, Ma L, Yang Z, Li J, Liu B. Free Radic Biol Med. 2016 Oct 27.

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Pharmacological inhibition of NOX4 ameliorates alcohol-induced liver injury in mice through improving oxidative stress and mitochondrial function.

Sun Q, Zhang W, Zhong W, Sun X, Zhou Z. Biochim Biophys Acta. 2016 Sep 12;1861(1 Pt A):2912-2921.

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Role of muscular eNOS in skeletal arteries: Endothelium-independent hypoxic vasoconstriction of the femoral artery is impaired in eNOS-deficient mice.

Kim HJ, Yoo HY, Lin HY, Oh GT, Zhang YH, Kim SJ. Am J Physiol Cell Physiol. 2016 Sep 1;311(3):C508-17.

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NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages.

Moon JS, Nakahira K, Chung KP, DeNicola GM, Koo MJ, Pabón MA, Rooney KT, Yoon JH, Ryter SW, Stout-Delgado H, Choi AM. Nat Med. 2016 Sep;22(9):1002-12.

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NOX4-derived reactive oxygen species limit fibrosis and inhibit proliferation of vascular smooth muscle cells in diabetic atherosclerosis.

Di Marco E, Gray SP, Kennedy K, Szyndralewiez C, Lyle AN, Lassègue B, Griendling KK, Cooper ME, Schmidt HH, Jandeleit-Dahm KA. Free Radic Biol Med. 2016 Aug;97:556-67

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Airway smooth muscle NOX4 is upregulated and modulates ROS generation in COPD.

Hollins F, Sutcliffe A, Gomez E, Berair R, Russell R, Szyndralewiez C, Saunders R, Brightling C. Respir Res. 2016 Jul 19;17(1):84

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Therapeutic potential of NADPH oxidase 1/4 inhibitors.

Teixeira G, Szyndralewiez C, Molango S, Carnesecchi S, Heitz F, Wiesel P, Wood JM. Br J Pharmacol. 2016 Jun 7.

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Off-Target Vascular Effects of Cholesteryl Ester Transfer Protein Inhibitors Involve Redox-Sensitive and Signal Transducer and Activator of Transcription 3-Dependent Pathways.

Rios FJ, Lopes RA, Neves KB, Camargo LL, Montezano AC, Touyz RM. J Pharmacol Exp Ther. 2016 May;357(2):415-22.

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NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells.

Jayavelu AK, Müller JP, Bauer R, Böhmer SA, Lässig J, Cerny-Reiterer S, Sperr WR, Valent P, Maurer B, Moriggl R, Schröder K, Shah AM, Fischer M, Scholl S, Barth J, Oellerich T, Berg T, Serve H, Frey S, Fischer T, Heidel FH, Böhmer FD. Leukemia. 2016 Feb;30(2):473-83

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Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina.

Deliyanti D, Wilkinson-Berka JL. J Neuroinflammation. 2015 Jul 30;12:136.

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Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes.

Rios FJ, Neves KB, Nguyen Dinh Cat A, Even S, Palacios R, Montezano AC, Touyz RM. J Pharmacol Exp Ther. 2015 Apr;353(1):27-34.

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Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement.

Altenhöfer S, Radermacher KA, Kleikers PW, Wingler K, Schmidt HH. Antioxid Redox Signal. 2015 Aug 10;23(5):406-27.

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NADPH oxidase enzymes in skin fibrosis: molecular targets and therapeutic agents.

Babalola O, Mamalis A, Lev-Tov H, Jagdeo J. Arch Dermatol Res. 2014 May;306(4):313-30.

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NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis.

Goettsch C, Babelova A, Trummer O, Erben RG, Rauner M, Rammelt S, Weissmann N, Weinberger V, Benkhoff S, Kampschulte M, Obermayer-Pietsch B, Hofbauer LC, Brandes RP, Schröder K. J Clin Invest. 2013 Nov;123(11):4731-8

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The Nox1/4 Dual Inhibitor GKT137831 or Nox4 Knockdown Inhibits Angiotensin-II-Induced Adult Mouse Cardiac Fibroblast Proliferation and Migration. AT1 Physically Associates With Nox4.

Somanna NK, Valente AJ, Krenz M, Fay WP, Delafontaine P, Chandrasekar B

J Cell Physiol. 2016 May;231(5):1130-41. doi: 10.1002/jcp.25210. Epub 2015 Oct 19.

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Early oxidative damage induced by doxorubicin: Source of production, protection by GKT137831 and effect on Ca2+ transporters in HL-1 cardiomyocytes.

Asensio-López MC, Soler F, Sánchez-Más J, Pascual-Figal D, Fernández-Belda F, Lax A

Arch Biochem Biophys. 2016 Feb 22;594:26-36. doi: 10.1016/ [Epub ahead of print]

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NADPH oxidase 4 over-expression is associated with epithelial ciliary dysfunction in neutrophilic asthma.

Wan WH, Hollins F, Haste L, Woodman L, Hirst RA, Bolton S, Gomez E, Sutcliffe A, Desai D, Chachi L, Mistry V, Szyndralewiez C, Wardlaw A, Saunders R, O'Callaghan C, Andrew PW, Brightling C

Chest. 2016 Feb 2. pii: S0012-3692(16)00518-3. doi: 10.1016/j.chest.2016.01.024. [Epub ahead of print]

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NOX4 in Mitochondria: Yeast Two-Hybrid-Based Interaction with Complex I Without Relevance for Basal Reactive Oxygen Species?

Hirschhäuser C, Bornbaum J, Reis A, Böhme S, Kaludercic N, Menabò R, Di Lisa F, Boengler K, Shah AM, Schulz R, Schmidt HH

Antioxid Redox Signal. 2015 Nov 10;23(14):1106-12. doi: 10.1089/ars.2014.6238. Epub 2015 Aug 3.

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Excess TGF-β mediates muscle weakness associated with bone metastases in mice.

Waning DL, Mohammad KS, Reiken S, Xie W, Andersson DC, John S, Chiechi A, Wright LE, Umanskaya A, Niewolna M, Trivedi T, Charkhzarrin S, Khatiwada P, Wronska A, Haynes A, Benassi MS, Witzmann FA, Zhen G, Wang X, Cao X, Roodman GD, Marks AR, Guise TA

Nat Med. 2015 Nov;21(11):1262-71. doi: 10.1038/nm.3961. Epub 2015 Oct 12.

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IL-1beta mediates MMP secretion and IL-1beta neosynthesis via upregulation of p22phox and NOX4 activity in human articular chondrocytes

Rousset F, Hazane-Puch F, Pinosa C, Nguyen MV, Grange L, Soldini A, Rubens-Duval B, Dupuy C, Morel F, Lardy B

Osteoarthritis Cartilage. 2015 NOV;23(11):1972-80. doi: 10.1016/j.joca.2015.02.167.

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Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease

You YH, Quach T, Saito R, Pham J, Sharma K.

J Am Soc Nephrol. 2015 Jul 22. pii: ASN.2015030302. [Epub ahead of print]

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NOX4 NADPH Oxidase-Dependent Mitochondrial Oxidative Stress in Aging-Associated Cardiovascular Disease

Vendrov AE, Vendrov KC, Smith A, Yuan J, Sumida A, Robidoux J, Runge MS, Madamanchi NR.

Antioxid Redox Signal. 2015 Jul 14. [Epub ahead of print]

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Increased Expression of NAPDH Oxidase 4 (NOX4) in Systemic Sclerosis Dermal Fibroblasts: Regulation by Transforming Growth Factor ß

Piera-Velazquez S, Makul A, Jimenez SA.

Arthritis Rheumatol. 2015 Jun 19. doi: 10.1002/art.39242. [Epub ahead of print]

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Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice

Bettaieb A, Jiang JX, Sasaki Y, Chao TI, Kiss Z, Chen X, Tian J, Katsuyama M, Yabe-Nishimura C, Xi Y, Szyndralewiez C, Schröder K, Shah A, Brandes RP, Haj FG, Török NJ.

Gastroenterology. 2015 Aug;149(2):468-480.e10. doi: 10.1053/j.gastro.2015.04.009. Epub 2015 Apr 14.

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Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina

Deliyanti D, Wilkinson-Berka JL.

J Neuroinflammation. 2015 Jul 30;12:136. doi: 10.1186/s12974-015-0363-z.

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Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation

Lan T, Kisseleva T, Brenner DA.

PLoS One. 2015 Jul 29;10(7):e0129743. doi: 10.1371/journal.pone.0129743. eCollection 2015.

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Chemerin Regulates Crosstalk Between Adipocytes and Vascular Cells Through Nox

Neves KB, Nguyen Dinh Cat A, Lopes RA, Rios FJ, Anagnostopoulou A, Lobato NS, de Oliveira AM, Tostes RC, Montezano AC, Touyz RM.

Hypertension. 2015 Sep;66(3):657-66. doi: 10.1161/HYPERTENSIONAHA.115.05616. Epub 2015 Jul 6.

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NADPH oxidase 4 induces cardiac fibrosis and hypertrophy through activating Akt/mTOR and NFκB signaling pathways

Zhao QD, Viswanadhapalli S, Williams P, Shi Q, Tan C, Yi X, Bhandari B, Abboud HE.

Circulation. 2015 Feb 17;131(7):643-55. doi: 10.1161/CIRCULATIONAHA.114.011079. Epub 2015 Jan 14.

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Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes

Gorin Y, Cavaglieri RC, Khazim K, Lee DY, Bruno F, Thakur S, Fanti P, Szyndralewiez C, Barnes JL, Block K, Abboud HE.

Am J Physiol Renal Physiol. 2015 Jun 1;308(11):F1276-87. doi: 10.1152/ajprenal.00396.2014. Epub 2015 Feb 4.

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Matrix metalloproteinase-3 causes dopaminergic neuronal death through Nox1-regenerated oxidative stress

Choi DH, Kim JH, Seo JH, Lee J, Choi WS, Kim YS.

PLoS One. 2014 Dec 23;9(12):e115954. doi: 10.1371/journal.pone.0115954. eCollection 2014.

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Nicotine mediates oxidative stress and apoptosis through cross talk between NOX1 and Bcl-2 in lung epithelial cells

Zanetti F, Giacomello M, Donati Y, Carnesecchi S, Frieden M, Barazzone-Argiroffo C.

Free Radic Biol Med. 2014 Nov;76:173-84. doi: 10.1016/j.freeradbiomed.2014.08.002. Epub 2014 Aug 20.

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Premature skin aging features rescued by inhibition of NADPH oxidase activity in XPC-deficient mice

Hosseini M, Mahfouf W, Serrano-Sanchez M, Raad H, Harfouche G, Bonneu M, Claverol S, Mazurier F, Rossignol R, Taieb A, Rezvani HR.

J Invest Dermatol. 2015 Apr;135(4):1108-18. doi: 10.1038/jid.2014.511. Epub 2014 Dec 1.

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NOX1 is responsible for cell death through STAT3 activation in hyperoxia and is associated with the pathogenesis of acute respiratory distress syndrome.

Carnesecchi S, Dunand-Sauthier, Zanetti F, Singovski G, Deffert C, Donati Y, Cagarelli T, Pache JC, Krause KH, Reith W, Barazzone-Argiroffo C

Int J Clin Exp Pathol. 2014 Jan 15;7(2):537-51. eCollection 2014.

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Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy.

Jha JC, Gray SP, Barit D, Okabe J, El-Osta A, Namikoshi T, Thallas-Bonke V, Wingler K, Szyndralewiez C, Heitz F, Touyz RM, Cooper ME, Schmidt HH, Jandeleit-Dahm KA.

J Am Soc Nephrol. 2014 Jun;25(6):1237-54. doi: 10.1681/ASN.2013070810.

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Reversal of persistent fibrosis in aging by targeting nox4-nrf2 redox imbalance.

Hecker L, Logsdon NJ, Kurundkar D, Kurundkar A, Bernard K, Hock T, Meldrum E, Sanders YY, Thannickal VJ

Sci Transl Med. 2014 Apr 9;6(231):231ra47. doi: 10.1126/scitranslmed.3008182.

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Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune-inflammatory responses in diabetic Apoe(-/-) mice

Di Marco E, Gray SP, Chew P, Koulis C, Ziegler A, Szyndralewiez C, Touyz RM, Schmidt HH, Cooper ME, Slattery R, Jandeleit-Dahm KA

Diabetologia. 2014 Mar;57(3):633-42. doi: 10.1007/s00125-013-3118-3. Epub 2013 Nov 30.

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Knock, knock: Who's there? Nox1. Circulation (2013)

Hana A. Itani, Sergey Dikalov and David G. Harrison

Circulation. 2013 May 7

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Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

Jha JC, Gray SP, Barit D, Okabe J, El-Osta A, Namikoshi T, Thallas-Bonke V, Wingler K, Szyndralewiez C, Heitz F, Touyz RM, Cooper ME, Schmidt HH, Jandeleit-Dahm KA

J Am Soc Nephrol. 2014 Feb 7.

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NADPH Oxidase, NOX1, Mediates Vascular Injury in Ischemic Retinopathy

Wilkinson-Berka JL, Deliyanti D, Rana I, Miller AG, Agrotis A, Armani R, Szyndralewiez C, Wingler K, Touyz RM, Cooper ME, Jandeleit-Dahm KA, Schmidt HH

Antioxid Redox Signal. 2013 Oct 30. [Epub ahead of print]

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Nox1 Plays a Key Role in Diabetes Accelerated Atherosclerosis. Circulation (2013).

Gray SP, Di Marco E, Okabe J, Szyndralewiez C, Heitz F, Montezano AC, de Haan JB, Koulis C, El-Osta A, Andrews KL, Chin-Dusting JP, Touyz RM, Wingler K, Cooper ME, Schmidt HH, Jandeleit-Dahm KA

Circulation. 2013 May 7

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Nox4 and diabetic nephropathy: with a friend like this, who needs enemies? Free Radic Biol Med (2013).

Gorin Y, Block K

Free Radic Biol Med. 2013 Mar 23

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Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes. Clinical Science (2013).

Sedeek M, Gutsol A, Montezano AC, Burger D, Nguyen Dinh CatA, Kennedy CR, Burns KD, Cooper ME, Jandeleit-Dahm K, Page P, Szyndralewiez C, Heitz F, Hebert RL, Touyz RM

Clinical Science, 2013 Feb 1; 124(3):191-202. doi: 10.1042/CS20120330

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The Nox4 Inhibitor, GKT137831, Attenuates Hypoxia-Induced Pulmonary Vascular Cell Proliferation. Am J Respir Cell Mol Biol (2012).

Green DE, Murphy TC, Kang BY, Kleinheinz JM, Szyndralewiez C, Page P, Sutliff RL, Hart CM

Am J Respir Cell Mol Biol. 2012 Sep 28. [Epub ahead of print] PMID:22904198

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Nicotinamide adenine dinucleotide phosphate oxidase (nox) in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology (2012).

Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C, Page P, A Brenner D.

Hepatology. 2012 Jul 14. doi: 10.1002/hep.25938

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Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo. Free Radic Biol Med (2012).

Joy X. Jiang, Xiangling Chen, Nobuko Serizawa, Cédric Szyndralewiez, Patrick Page, Katrin Schröder, Ralf P. Brandes, Sridevi Devaraj, Natalie J. Török

Free Radic Biol Med. 2012 Jul 15;53(2):289-96.

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NOX5 in human spermatozoa: expression, function, and regulation. J Biol Chem (2012).

Musset B, Clark RA, DeCoursey TE, Petheo GL, Geiszt M, Chen Y, Cornell JE, Eddy CA, Brzyski RG, El Jamali A.

J Biol Chem. 2012 Mar 16;287(12):9376-88. Epub 2012 Jan 30.

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Differential regulation of Nox1, Nox2 and Nox4 in vascular smooth muscle cells from WKY and SHR. J Am Soc Hypertens (2011).

Briones AM, Tabet F, Callera GE, Montezano AC, Yogi A, He Y, Quinn MT, Salaices M, Touyz RM.

J Am Soc Hypertens. 2011 May-Jun;5(3):137-53. Epub 2011 Mar 17.

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Design, Synthesis and Biological Activity of original Pyrazolo-Pyrido-Diazepine, -Pyrazine and -Oxazine Dione Derivatives as Novel Dual Nox4/Nox1 Inhibitors. Bioorganic and Medicinal Chemistry (2011).

F. Gaggini, B. Laleu, M. Orchard, L. Fioraso-Cartier, L. Cagnon, S. Molango, A. Gradia, G. Duboux, C. Merlot, F. Heitz, C. Szyndralewiez, P. Page

Bioorganic and Medicinal Chemistry, 2011, Vol. 19, Issue 23, pp6989-6999.

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Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPAR-alpha Mediated Mechanism. PloS ONE (2011).

S. Garrido-Urbani, S. Jemelin, C. Deffert, S. Carnesecchi, O. Basset, C. Szyndralewiez, F. Heitz, P. Page, X. Montet, L. Michalik, J.L. Arbiser, C. Ruegg, B.A. Imhof

PloS ONE, 2011, Vol.6, Issue 11, e14665

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First-in-Class, Potent and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis. Journal of Medicinal Chemistry (2010).

B. Laleu, F. Gaggini, M. Orchard, L. Fioraso-Cartier, L. Cagnon, S. Molango, A. Gradia, G. Duboux, C. Merlot, F. Heitz, C. Szyndralewiez, P. Page

Journal of Medicinal Chemistry, 2010, 53 (21), 7715-30

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Critical Role of Nox4-Based NADPH oxidase in glucose-induced oxidative stress in kidney - Implications in type 2 diabetic nephropathy. American Journal of Physiology - Renal Physiology (2010).

M. Sedeek, G. Callera, A. Montezano, A. Gutsol, F. Heitz, C. Szyndralewiez, P. Page, C. Kennedy, K. Burns, R. Touyz, and R. Hebert

American Journal of Physiology - Renal Physiology, 2010, 299 (6), F1348-58

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NADPH oxidases regulates CD44 and hyaluronic acid expression in thrombin treated vascular smooth muscle cells and in atherosclerosis. Journal of Biological Chemistry (2010).

Vendrov A.E., Madamanchi N., Liu X.L., Molnar K.C., Runge M., Szyndralewiez C., Page P., Runge M.S.,

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